With regard to the following diagram, where line A represents the slope of the Left Ventricular diastolic pressure:

  1. Which of the following would cause line A to shift to line B and line C?
  2. Noradrenaline would cause B, Metoprolol would cause C
  3. Noradrenaline would cause C, Metoprolol would cause B
  4. A fluid bolus would cause B, bleeding would cause C
  5. A fluid bolus would cause C, bleeding would cause B