V2ii: Terbutaline

Terbutaline

Terbutaline

Chemical

Enthanolamine derivative bronchodilator with tocolytic activities

Use

Uterine Hypercontractility (>5 contractions in 10 mins)

Presentation

5ml ampoule (5mg/5ml)

Dose

Draw up 25mcg/ml

Give IV 50mcg boluses up to 250mcg in total

Route

IV

Onset

Immediate

MoA

Selective b2 agonist

Preferential for B2 receptors on bronchial, vascular & uterine smooth muscles

PD

Relaxes smooth muscle and inhibits uterine contractions

PK

A

D

25% PPB

M

Liver CYP450

E

T1/2b 11-16hrs

90% excreted in urine unchanged

Adverse Effects

Foetal & maternal tachycardia

Foetal hypoglycaemia

Maternal hypotension

Tremor

HA

Nervousness

Arrythmia, tachycardia, palpitations

Muscle cramps

Hypokalaemia

Hyperglycaemia

C/I

IHD

HTN

Hyperthyroidism