Rocuronium
Chemical
Aminosteroid non-depolarising neuromuscular blocker
Use
- RSI
- Skeletal muscle paralysis for mechanical ventilation
Presentation
Clear, colourless, 10mg/ml
Fridge 4C
Dose
0.6mg/kg
1.2mg/kg RSI
Route
IV
Onset
60 sec RSI
DoA
Intermediate
MoA
Competitive antagonism of pre & post junctional nAChR
Prevents Ach binding receptors on motor end plate
Therefore prevents depolarisation
PD
MSK: paralysis
CVS: mild vagolysis
PK
A
IV
D
30% PPB
Vd 0.27L/kg
M
No metabolites
E
40% unchanged bile
35% unchanged urine
Adverse Effects
Anaphylaxis