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Pharmacopeia
MCQs
- 2023
- 2022
- 2021
- 2020
- 2019
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Syllabus
Year
Pharmacopeia
MCQs
- 2023
- 2022
- 2021
- 2020
- 2019
MPS
Test Yo’Self
Hacks
About

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Syllabus

B: Pharmacokinetics

Bi: Explain the concept of pharmacokinetic modeling of single and multiple compartment models

Bi: Explain the concept of pharmacokinetic modelling of single and multiple compartment models

Bii: Describe absorption and factors that will influence it

Bii / 14A20: Describe the factors affecting drug absorption from the GI tract

Biii: Describe factors influencing the distribution of drugs

Biii / 18B07: Describe protein binding and its significance in pharmacology
Biii / 19A05 / 15B12: Volume of distribution
Biii / 20A15 / 17B22: Define bioavailability (10 marks). Outline factors which affect it (90 marks)

Biv: Describe the mechanisms of drug clearance and metabolism

Biv / 16A08: Describe the characteristics of a drug that influence its excretion by the kidneys
Biv / 16A20: Outline the role of the liver in drug pharmacokinetics
Biv / 19B15: Define clearance and HER. Describe the role of the liver in drug clearance w examples
Biv: Describe drug clearance, its determinants and how it is estimated
Biv: Discuss the pharmacokinetic factors that affect drug half life

Bv: Explain the kinetics of an intravenous bolus and infusion

Bv: Zero & First Order Kinetics

Bvi: Describe the concepts of effect-site concentration and context sensitive half-time

Bvi / 18A05: Compare and contrast the pharmacokinetic and pharmacodynamics of IV fentanyl and IV remifentanil (60 marks). Discuss the concept of context sensitive half-time using these drugs as examples (40 marks)

Bvii: Explain clinical drug monitoring with regard to peak and trough concentrations, minimum therapeutic concentration and toxicity

Bvii: Explain clinical drug monitoring with regards to peak & trough concentrations, minimum therapeutic concentration & toxicity

Bviii: Describe the pharmacokinetics of drugs in the epidural and subarachnoid space

Bviii: Describe the pharmacokinetics of drugs in epidural and subarachnoid space

B: SYL2017 Pharmacokinetics

How pharmacokinetics are affected by extremes of age, obesity, pregnancy and critical illness

B SYL2017 / 22A01: Outline the effects of critical illness on drug pharmacokinetics, including examples
B SYL2017: Describe how pharmacokinetics are affected by ageing
B SYL2017: Neonate PK changes
B SYL2017: OBA with shock

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