Regarding the Haldane effect, which statement is correct?

  1. Describes the rightward shift of the oxygen-haemoglobin dissociation curve in the tissues due to the effect of CO2 binding to haemoglobin
  2. Describes the rightward shift of the oxygen-haemoglobin dissociation curve with an increase in temperature
  3. Governs the respiratory exchange ratio for O2 uptake and CO2 production
  4. The affinity of haemoglobin for CO2 is reduced by the binding of O2 in the lungs