Flucloxacillin

Class

β-lactam

Dose

250mg qid

Mechanism

Cell Wall Inhibitor

MoA

Inhibits cell wall (peptidoglycan) synthesis

 

Mimics D-Ala-D-Ala (substrate required for cell wall synthesis)

Transpeptidases instead bind to b-lactam nucleus

Time v Conc

Time > MIC

Post Dose Effect

Short

SPectrum

Covers

Doesnt

  • Limited G+ Spectrum
  • MSSA
  • G-
  • MRSA
  • Anaerobes
  • Enterococcus

Indications

  • Skin and soft tissue infections
  • Staph Endocarditis

PK

A

80% OBA

D

95% PPB

M

Minimally metabolized by liver – but many side effects

E

Renally excreted

AE

  • Cholestatic
  • Jaundice
  • Pseudomembranous colitis
  • Nephritis
  • Fever

Resistance

b-lactamase producing bacteria

Monitoring

  • Renal fn
  • LFTs