Prochlorperazine

Chemical

A phenothiazine dopamine antagonist antiemetic

Use

  1. Nausea & vomiting
  2. Vertigo

Presentation

Tablets 3/5/25mg

Vial 12.5mg/mL

Dose/Route

5 – 20mg TDS

MoA

Central D2 antagonism @ CTZ

∴↑ threshold for vomiting

PD

GI – ↑LES tone

CNS – neuroleptic

CVS – α1 antagonism → hypoT

PK

A

Poor PO absorption 0 – 16%

D

High PPB 99%

VD 22L/kg

M

Significant 1st pass metabolism CYP3A4 & CYP2D6

E

t ½ 6 – 8hrs

Adverse Effects

Extrapyramidal reactions

Jaundice

Leucopaenia

Rashes

Neuroleptic malignant syndrome