Fresh Frozen Plasma

Chemical

FFP is all the clotting factors present in whole blood

Collection

Single whole blood donation

  • Frozen within 8hrs
  • Stored 1yr ≤ -25°C to minimise loss of F V & VIII
  • Thawed in H2O bath ~20 mins
  • Used immediately or can be stored @ 4°C to use <24hrs

Storage

  • Frozen within 8hrs
  • Stored 1yr ≤ -25°C to minimise loss of F V & VIII
  • Thawed in H2O bath ~20 mins
  • Used immediately or can be stored @ 4°C to use <24hrs

Use

Warfarin reversal

MoA (mechanism)

Replaces clotting factors depleted by warfarin

Centics: not a factor concentrate

∴ multiple units need to be administered for successful with reversal

Requires: blood group, facilities for storage & thawing

→Given with Vit K to sustain effect