Atracurium

Chemical

Benzylisoquinolinium

Use

Paralysis

Presentation

Clear, colourless, 10mg/ml

Fridge

Dose

0.6mg/kg

Route

IV

Onset

2mins

DoA

Intermediate

MoA

Post-junctional competitive inhibition nAChR

PD

CVS – favourable as minimal CVS effects

RESP – Apnoea

PK

D

82%PPB

M

Hoffman degradation & ester hydrolysis

E

Metabolites in urine & feces

Adverse Effects

Histamine release – cutaneous flushing, hypotension, bronchospasm