Cii: Quantal dose response curve

  • Describes proportion of population responding to a drug
  • Quantal because either happens or doesn’t (“all-or-nothing”)e. 25mg atenolol → drops BP 5mmHg → YES/NO?
Response Curve

INFO OBTAINED

  • ED50 = dose that produces desired effect in 50% population
  • LD50 = lethal dose in 50% population
  • TD50 = toxic dose in 50% population
Therapeutic Index

→ Hopefully a big no. with large therapeutic index