I1iv: Outline the composition and functions of lymph
Defintions
Lymph = fluid which has entered lymphatic vessels from interstitial spaces
Lymph Fluid Content
- Derived from ISF → very similar composition
- Contains all clotting factors (so can clot)
- No platelets
- Low fibrinogen (because larger MW 340,000)
- After high fat meal, lymph draining bowel will have ‘milky’ appearance due to presence of chylomicrons
- Lymph coming from liver will have higher [protein] because hepatic sinusoids have low reflection coefficient
Anatomy
- Lymphatic capillaries = everywhere EXCEPT CNS, bone & cartilage
- Lymph vessels are blind-ending
- Made of endothelial cells with a highly permeable BM
- Possess flap valves between endothelial cells → permit one way entry of ISF
- Lymph caps drain into larger lymph vessels
- All lymph passes through LNs
- Lymph returns to circulation via:
- THORACIC DUCT → junction of L) subclavian & LIJ
- R) LYMPHATIC DUCT → junction of R) subclavian & RIJ
Function
1) Return Fluid
- Starling’s Forces result in:
- Net Filtration ~20mL/min at arterial end
- Net reabsorption ~18mL/min
- ∴2mL/min escapes into interstitium
- This fluid is returned to circulation by lmph at a rate of 2mL/min (at rest)
2) Return Protein
- Protein of lymph is low & mimics ISF [protein] EXCEPT liver, which has low ‘s’
- Protein is returned to circulation by lymph vessels → NB: this is the only way that any protein which has escaped vascular compartment can be returned because it cannot re-enter vessels
3) Immunological Role
- LNs contain macrophages
- Filter & phagocytose bacteria & debris
- LCs also present → proliferate in response to Ag’s
4) Fat Transport
- Fat transported as chylomicrons reach circulation by thoracic duct (bypassing portal circulation)
Lymph Flow
- Lymph flow 2mL/min (to return fluid from ISF)
- EXTRINSIC & INTRINSIC factors promote this
- Extrinsic: tissue pressure, skeletal m. activity, arterial pulsations → all compress lymph vessels
- Intrinsic: smooth m. wall contraction in large lymph vessels & presence of 1-way-valves → ensure unidirectional flow
- ↑flow with exercise
- If ISF volume > lymph drainage → OEDEMA