Q3ii: Outline the methods for assessing platelet function
Platelets
Number / form
- Platelet count → size + no.
- Blood film → morphology
Coagulation
- ACT, TEG/ROTEM, bleeding time
Aggregation
Light transmission platelet aggregation
- Photo-optical measurement of light transmission ↑in relation to platelet aggregation
- Screens for bleeding tendency, platelet defects & monitoring anti-platelet drugs
Shear stress
PFA – 100
- Time evaluation of high shear whole blood flow blocked by platelet plug into a hole on activated surface
- Assesses bleeding risk
- Reveals vWD