V2i: Ergotamine
Ergotamine
Ergotamine
Chemical
Ergot alkaloid
Use
PPH
Cluster headaches
Migraines
Presentation
Tablets
Vial
Also comes in combination with oxytocin (Syntometrine = 0.5mg ergometrine and 5IU oxytocin)
Dose
Single 250mcg IM dose in first line Mx of PPH due to uterine atony
IV – administer 25-50mcg boluses q3mins up to total 250mcg
Route
IM/IV
Onset
6-7mins IM
DoA
2-4hrs
MoA
Acts directly on uterine smooth muscle to increase tone, rate and amplitude of tetanic contraction
a1/5HT receptor agonist
PD
Vasculature: powerful vasoconstriction
PK
A
D
NA
M
Hepatic metabolism by undefined pathways
E
T1/2b 2hrs
Adverse Effects
N+V
HTN
Abdominal pain
C/I
HTN, IHD, Retained placenta/pre-eclapmsia/eclampsia