Which of the following agents inhibits factor Xa in-vivo?

  1. Aprotinin – pancreatic trypsin inhibitor
  2. Epsilon aminocaproic acid – synthetic inhibitor of the plasmin-plasminogen system
  3. Rivaroxaban – free Xa & Xabound in complex inhibits
  4. Tranexamic acid – binds lysine on plasminogen and presvents it being converted to plasmin