Azithromycin
Class
Macrolide
Dose
500mg od
Mechanism
Bacterostatic
MoA
50S ribosomal inhibitor
Time v Concentration
Time > MIC
Post dose effect
Extremely prolonges. t1/2b 3 days
Spectrum
Covers
Doesn't Cover
Simple G +ves and G -ves
Anaerobes
Serratia
Klebsialla
Most Gram -ves
Enterococcus
Indications
CAP (mild infection)
Severe LRTI w combination therapy
Potent immunomodulation ie chronic beonchiectasis, Cystic Fibrosis
PK
A
OBA 40%
D
Vd 30L/kg
M
Not metabolised
E
Excreted into bile -> feces. <10% urine
A/E
CVS – QT prolongation
GI- cramps, nausea, diarrhea, anorexia, pancreatitis
Endo – hyperglycaemia
CNS – headache, fatigue
Liver – hepatotoxicity, jaundice
Monitoring
Hepatic & renal fn