Ceftriaxone

Class

3rd Generation Cephalopsorin

Dose

1g (IV) q12h (start dose)

 

2g (IV) q12h (meningitis)

 

1g (IV) od (maintenance)

Mechanism

Bactericidal

MoA

Binds penicillin binding protein (PBP) on bacterial cell wall → inhibits cell wall synthesis → bactericidal

Good penetration \ useful for Pyelonephritis, BBB – menigitis

Time v Conc

Time > MIC

Post Dose Effect

Short

SPectrum

Covers

Doesnt

G+

  • Streptococcus Pneumoniae
  • Streptococci
  • Staphylococci (some cover)

G-

  • E Coli
  • Hemophilus
  • Klebsiella
  • Pseudomonas
  • Enterococcus
  • ESCAPIMS
  • MRSA
  • Listeria
  • Anaerobes

Indications

  • Severe CAP (with Azithromycin)
  • HAP
  • Abdominal infections (with Metronidazole)

PK

A

IV and IM

D

Distribute widely into most body tissues

PPB 95%

M

Minimal metabolism

E

Renal excretion, some biliary excretion so avoid in neonates

AE

  • Acute Interstitial Nephritis

Monitoring

  • Renal fn
  • LFTs