Ampicillin

Class

Aminopenicillin

Dose

500mg-1000mg IV q6h

Mechanism

Cell Wall Inhibitor

MoA

Inhibits cell wall (peptidoglycan) synthesis by binding to penicillin binding proteins

Time v Conc

Time > MIC

Post Dose Effect

Short

SPectrum

Covers

Doesnt

  • G+
  • G-

  • B-lactamase producing bacteria

  • Pseudomonas

Indications

  • Intermediate spectrum
  • URTI
  • UTI
  • Intra-abdominal infections

PK

A

Good IM absorption

D

PPB 20%

M

Minimal heparic metabolism

E

Renally excreted

AE

  • Acute Interstitial Nephritis
  • Allergy (1/10,000 – all penicillins)
  • Seizures  (high dose)

Resistance

b-lactamase producing bacteria

Monitoring

  • Renal fn
  • LFTs