Ampicillin
Class
Aminopenicillin
Dose
500mg-1000mg IV q6h
Mechanism
Cell Wall Inhibitor
MoA
Inhibits cell wall (peptidoglycan) synthesis by binding to penicillin binding proteins
Time v Conc
Time > MIC
Post Dose Effect
Short
SPectrum
Covers
Doesnt
- G+
- G-
B-lactamase producing bacteria
Pseudomonas
Indications
- Intermediate spectrum
- URTI
- UTI
- Intra-abdominal infections
PK
A
Good IM absorption
D
PPB 20%
M
Minimal heparic metabolism
E
Renally excreted
AE
- Acute Interstitial Nephritis
- Allergy (1/10,000 – all penicillins)
- Seizures (high dose)
Resistance
b-lactamase producing bacteria
Monitoring
- Renal fn
- LFTs