Augmentin

Class

Penicillin; B-lactam & b-lactamase inhibitor

Dose

1.2g tds (IV)

Mechanism

Cell Wall Inhibitor

MoA

  1. Amoxicillin – binds penicillin binding proteins and inhibits bacterial cell wall synthesis

  2. Clavulanic acid – b-lactamase inhibitor

Time v Conc

Time

Post Dose Effect

Short

Spectrum

Covers

Doesnt

  • Gram positive
    • Better Staph cover than Ampicillin
  • Anaerobes
  • Pseudomonas
  • ESCAPIMS
  • ESBLs

Indications

Empyema/Lung abscess (1st line)

PK

A

OBA 80%

D

PPB Clavulanic 25%; Amoxicillin 18%

M

E

Excreted unchanged Clavulanic 30%; Amoxicillin 60%

AE

  • Sodium load (62.9mg) per vial
  • C diff
  • LFT abnormalities (bc of Clavulanic component)

Monitoring

UEC, LFT, FBC