Tazocin
Class
Antipseudomonal Penicillin with β-lactamase inhibitor
Dose
4.5g q8h
Mechanism
Cell Wall Inhibitor
MoA
Inhibits cell wall (peptidoglycan) synthesis
Mimics D-Ala-D-Ala (substrate required for cell wall synthesis)
Transpeptidases instead bind to b-lactam nucleus
Time v Conc
Time Dependent -> time spent above minimal inhibitory concentration determines efficacy
Post Dose Effect
Short 2hrs – bactericidal
SPectrum
Covers
Doesnt
- MSSA
- Streptococci & Enterococci
- Neisseria Meningitidis/Gonorrhoea
- Many Gram -ves including Pseudomonas
- Anaerobes
- MRSA
- VRE
- ESCAPIMS
Indications
- V Broad Spectrum
- Hospital acquired infections
- Intra-abdominal infections
- Neutropenic Sepsis
PK
A
IV only
D
- PPB 20%
- Vd 0.2L/kg
M
Minor hepatic metabolism
E
- Renally excreted
- Needs dose adjusted in renal impairment
AE
- High Na+ load
- Interacts w Vecuronium – prolongs neuromuscular blockade
Monitoring
- Renal fn
- LFTs