Acivlovir

Class

Antiviral

Dose

10mg/kg tds

Spectrum

Anti-HSV (herpes viruses)

MoA

• Inhibits viral DNA polymerase
• Incorporates into and terminates the growing viral DNA chane

Time v Conc

Indications

Herpes

PK

A

• Slow and poor OBA

D

• Widely distributed
• Low PPB <10%

M

E

• Renal excretion

AE

• Rash
• GI upset
• Hepatic & Renal impairment
• Blood dyscrasias

Resistance

Mutations

Monitoring

LFT, renal fn