Oseltamivir
Class
Antiviral
Dose
75mg bd po
Spectrum
Influenza
MoA
- Reversible inhibitor of neuraminidase
- Virion release from infected cells then spread to resp tract are inhibited bc this enzyme is blocked
Time v Conc
Indications
Influenza
PK
A
Prodrug has good 80% OBA (Oseltamivir-phosphate)
D
PPB low
M
Rapid extensive de-esterefication and conversion to O-carboxylate by liver
E
O-carboxylate elimin by glom filtration
AE
- GI upset – nausea, vom
- Headache
- Skin rashes