Angiotensin Receptor Blockers

Use

  1. Hypertension
  2. Delay progression of diabetic nephropathy
  3. CCF
  4. ACEi intolerance

Presentation

Tablets

Dose

40 – 80mg BD

Route

PO

Onset

2 hrs

MoA

  • Antagonises AII at AT1 receptors

∴

→ Dilates arteries & veins

→ ↓ symp. activity

→ Promotes renal excretion of Na+ & H2O

→ Inhibits cardiac remodelling

PD

CVS – ↓BP

PK

VALSARTAN

A

30% OBA

D

95% PPB

M

80% excreted unchanged

E

80% excreted & absorbed in faeces

t ½ B 7 hrs

Adverse Effects

Contraindicated in pregnancy & bilateral renal a. stenosis