Atenolol
Chemical
An amine
Use
- Hypertension
- Arrhythmias
- Post-AMI
Presentation
25/50/100mg tablets
Celar colourless solution 0.5mg/mL
Dose
(PO) 50 – 100mg OD
(IV) 2.5 – 10mg
Route
PO/IV
Onset
3 hrs
DoA
Prolonged OD dosing
MoA
Competitive antagonist at β1 adrenoreceptors
Antagonises effects of catecholamines
ECG: ↓HR
PD
CVS
- ↓SA node automaticity → ↓CHRONO
- ↓AV node conduction → ↓DROMO
- – VE INOTROPY
∴ ↓ myocardial O2 consumption
Metabolic
May see ↑TAGS, HDL & cholesterol
PK
A
OBA 50%
D
3% PPB
VD 0.7L/kg
M
<10% metabolised by liver
E
Excreted unchanged by kidneys
t ½ B 9hrs