Atenolol

Chemical

An amine

Use

  1. Hypertension
  2. Arrhythmias
  3. Post-AMI

Presentation

25/50/100mg tablets

Celar colourless solution 0.5mg/mL

Dose

(PO) 50 – 100mg OD

(IV) 2.5 – 10mg

Route

PO/IV

Onset

3 hrs

DoA

Prolonged OD dosing

MoA

Competitive antagonist at β1 adrenoreceptors

Antagonises effects of catecholamines

ECG: ↓HR

PD

CVS

  • ↓SA node automaticity → ↓CHRONO
  • ↓AV node conduction → ↓DROMO
  • – VE INOTROPY

∴ ↓ myocardial O2 consumption

 

Metabolic

May see ↑TAGS, HDL & cholesterol

PK

A

OBA 50%

D

3% PPB

VD 0.7L/kg

M

<10% metabolised by liver

E

Excreted unchanged by kidneys

t ½ B 9hrs