Glicazide

Chemical

Sulphonylurea

Tablets

40-160mg daily

2-8hrs

10-24h

Bind sulphonylurea receptor of b-cells in pancreas

Close K_ATP channels

Depolarises b -cell

Ca⁺⁺ influx

Exocytosis of insulin containing vesicles

Increase peripheral [insulin]

Pre-requisite of adequate b-cells function

Improves insulin dynamics

Rapid & good absorption

PPB 94%

Extensively in liver. Oxidised & hydroxylated derivatives, glucuronic acid conjugates

Metabolites in urine & faeces

Hypoglycaemia in starved state – must be stopped preop

Weight gain

GI disturbances

Elderly

Renal impairment

Fasting