Omeprazole

Use

  1. Pylori infection
  2. PUD
  3. GORD
  4. Dyspepsia
  5. Zollinger-Ellison Syndrome
  6. Upper GI bleed
  7. Stress ulcer prophylaxis

Presentation

Capsules

40mg powder vial

Dose / Route

  • 40mg (PO) OD
  • 40mg (IV) OD or BD

MoA

  • Irreversibly binds H/K/ATPase receptors of Parietal Cells
  • Non-competitive inhibition
  • Prevents H+ excretion
  • ↓gastric acid acidity

PD

GI – ↓ volume of gastric acid

PK

A

Rapid. Peaks in 30 mins. OBA 75%

D

95% PPB. VD 0.4L/kg

M

Hepatic by cytochrome P450, almost completely

E

Urinary, of metabolites, t ½ = 1 hr

Adverse Effects

  • Confusion
  • Drowsy
  • Blurry vision
  • Arrhythmias