Prochlorperazine
Chemical
A phenothiazine dopamine antagonist antiemetic
Use
- Nausea & vomiting
- Vertigo
Presentation
Tablets 3/5/25mg
Vial 12.5mg/mL
Dose/Route
5 – 20mg TDS
MoA
Central D2 antagonism @ CTZ
∴↑ threshold for vomiting
PD
GI – ↑LES tone
CNS – neuroleptic
CVS – α1 antagonism → hypoT
PK
A
Poor PO absorption 0 – 16%
D
High PPB 99%
VD 22L/kg
M
Significant 1st pass metabolism CYP3A4 & CYP2D6
E
t ½ 6 – 8hrs
Adverse Effects
Extrapyramidal reactions
Jaundice
Leucopaenia
Rashes
Neuroleptic malignant syndrome