Coloxyl & Senna
Chemical
Dual action laxative
Coloxyl = stool softner, Senna = stimulant
Presentation
Tablets
Dose
2tablets up to QID
Route
Oral
MoA
Senna = Stimulant laxative
→ Metabolised by gut bacteria
→ Active metabolites ↑H2O retention in colon & stimulate peristalsis
Coloxyl = Stool softner
↓ ST of stool allowing ↑fat & H2O content
PD
GI: ↑ peristalsis, ↑ water/fat content of stool
PK
A
<10% absorbed in metabolite form
D
N/A
M
Metabolised by gut bacteria
E
Excreted in urine, bile, faeces
Adverse Effects
Apoptosis due to ↑ p53 activity
Chronic use = carcinogenic associated with colon ca