Activated FVII (7)
Chemical
Recombinant protein
Dose
100mcg/kg
Needs 2 doses → 20 mins apart
Needs platelets for rFVIIa to be effective → consider after 10U PRBC, 8U FFP, 2U platelet, 2U cryo, TXA considered
T > 35, pH >7.2, Plats > 100, Fib > 100
MoA
TF + VIIa + platelets → platelet aggregation → production plat/fibrin matrix → haemostasis
AE
Thromboembolic cerebrovascular accidents, acute myocardial infarction, arterial thrombosis, pulmonary embolus, venous thrombosis, including deep vein thrombosis, and clotted access devices