Pancuronium
Chemical
A bis-quaternary aminosteroid
Use
Paralysis
Presentation
Clear solution 2mg/ml
Dose
0.05-0.1mg/kg
Route
IV
Onset
3-6min
DoA
Long > 50min
MoA
Post-junctional competitive inhibition nAChR
PD
CVS –
No histamine
Direct vagolytic effect
Sympathomimetic – NA release
↑HR, CO, BP
RESP –
Apnoea
PK
D
30% PPB
Vd 0.15L/kg
M
30% hepatic metabolism
E
40% unchanged in urine
prolonged w renal impairment
Adverse Effects
Anaphylaxis
Rash