Sugammadex
Chemical
Modified gamma-cyclodextrin
Use
Reversal of neuromuscular blockade induced by rocuronium/vecuronium
Presentation
Clear colourless pale yellow solution in 2ml or 5ml vials at a concentration 100mg/ml
Dose
4mg/kg
Route
IV
Onset
<3min
DoA (duration)
t1/2β 1.8hrs
MoA (mechanism)
Shaped like a donut, with a negatively-charged outer core (making it water-soluble in plasma), and a lipophilic inner core.
It attracts the positively charged aminosteroidal relaxants into the inner core, and the complex of drug is excreted in the urine.
PK
D
Vd 11-14L
Sugammadex-NMB complex does not bind to PPB
M
No metabolism
E
96% excreted in urine unchanged
Adverse Effects
Flushing, tachycardia, palpitations