Sugammadex

Chemical

Modified gamma-cyclodextrin

Use

Reversal of neuromuscular blockade induced by rocuronium/vecuronium

Presentation

Clear colourless pale yellow solution in 2ml or 5ml vials at a concentration 100mg/ml

Dose

4mg/kg

Route

IV

Onset

<3min

DoA (duration)

t1/2β 1.8hrs

MoA (mechanism)

Shaped like a donut, with a negatively-charged outer core (making it water-soluble in plasma), and a lipophilic inner core. 

It attracts the positively charged aminosteroidal relaxants into the inner core, and the complex of drug is excreted in the urine.

PK

D

Vd 11-14L

Sugammadex-NMB complex does not bind to PPB

M

No metabolism

E

96% excreted in urine unchanged

Adverse Effects

Flushing, tachycardia, palpitations