Vecuronium
Chemical
Aminosteroid non-depolarising neuromuscular blocker
Use
Skeletal muscle paralysis for mechanical ventilation
Particularly where minimal CVS effects are desired
Presentation
Vial of injection powder for reconstitution with water, 10mg/vial
Dose
0.1mg/kg bolus, then a continuous infusion of 1mcg/kg/min 20mins alter
Route
IV
Onset
2mins
Offset
Intermediate
DoA
20-40mins
MoA
Competitive antagonism of pre & post junctional nAChR
Prevents Ach binding receptors on motor end plate
Therefore prevents depolarisation
PD
MSK: paralysis
PK
A
IV
D
60-90% PPB
M
Liver deacetylation, active metabolites
Active metabolites
E
Metabolites primarily excreted in faeces by biliary elimination and some via urine
Adverse Effects
MSK: weakness