Vecuronium

Chemical

Aminosteroid non-depolarising neuromuscular blocker

Skeletal muscle paralysis for mechanical ventilation

Particularly where minimal CVS effects are desired

Vial of injection powder for reconstitution with water, 10mg/vial

0.1mg/kg bolus, then a continuous infusion of 1mcg/kg/min 20mins alter

2mins

Intermediate

20-40mins

Competitive antagonism of pre & post junctional nAChR

Prevents Ach binding receptors on motor end plate

Therefore prevents depolarisation

MSK: paralysis

60-90% PPB

Liver deacetylation, active metabolites

Active metabolites

Metabolites primarily excreted in faeces by biliary elimination and some via urine

MSK: weakness