Vecuronium

Chemical

Aminosteroid non-depolarising neuromuscular blocker

Use

Skeletal muscle paralysis for mechanical ventilation

Particularly where minimal CVS effects are desired

Presentation

Vial of injection powder for reconstitution with water, 10mg/vial

Dose

0.1mg/kg bolus, then a continuous infusion of 1mcg/kg/min 20mins alter

Route

IV

Onset

2mins

Offset

Intermediate

DoA

20-40mins

MoA

Competitive antagonism of pre & post junctional nAChR

Prevents Ach binding receptors on motor end plate

Therefore prevents depolarisation

PD

MSK: paralysis

PK

A

IV

D

60-90% PPB

M

Liver deacetylation, active metabolites

Active metabolites

E

Metabolites primarily excreted in faeces by biliary elimination and some via urine

Adverse Effects

MSK: weakness