Ibuprofen
Chemical
Proprionic acid derivative
Use
- Inflammatory MSK disorders
- Post op pain
Presentation
Tablets 200 – 600mg
Racemic mixture
R-enantiomer → converted to S-enantiomer → S is the pharmacologically active drug
Dose
20mg/kg/day divided doses
Route
PO
Onset
30 mins
DoA (duration)
2 – 4 hrs
MoA (mechanism)
- Non-selective COX enzyme inhibition
- ↓ synthesis of PGs, prostacyclin & thromboxane
= antiplatelet, analgesia, antipyretic
PD
CNS
- Analgesia
- Antipyretic
- Peripheral ↓ n. sensitisation to pain
CVS
- Oedema & exac HF
- Variable antiplatelet activity
Resp – bronchospasm
GI – GI ulceration, bleeding
GU
- ↓renal BF
- ↑urea
- Papillary necrosis
PK
A
OBA 80%
D
>99% PPB
VD 0.15L/kg
M
Hepatic → oxidation to inactive metabolites +/- conjugated prior to excretion
E
Metabolites via urine
t ½ 2 hrs
Adverse Effects
- Fluid retention
- Abdo pain
- N&V
- Vertigo
- Dizziness
- Dyspepsia