Ibuprofen

Chemical

Proprionic acid derivative

Use

  1. Inflammatory MSK disorders
  2. Post op pain 

Presentation

Tablets 200 – 600mg

Racemic mixture

R-enantiomer → converted to S-enantiomer → S is the pharmacologically active drug

Dose

20mg/kg/day divided doses

Route

PO

Onset

30 mins

DoA (duration)

2 – 4 hrs

MoA (mechanism)

  • Non-selective COX enzyme inhibition
  • ↓ synthesis of PGs, prostacyclin & thromboxane

= antiplatelet, analgesia, antipyretic

PD

CNS

  • Analgesia
  • Antipyretic
  • Peripheral ↓ n. sensitisation to pain

CVS

  • Oedema & exac HF
  • Variable antiplatelet activity

Resp – bronchospasm

GI – GI ulceration, bleeding

GU

  • ↓renal BF
  • ↑urea
  • Papillary necrosis

PK

A

OBA 80%

D

>99% PPB

VD 0.15L/kg

M

Hepatic → oxidation to inactive metabolites +/- conjugated prior to excretion

E

Metabolites via urine

t ½ 2 hrs

Adverse Effects

  • Fluid retention
  • Abdo pain
  • N&V
  • Vertigo
  • Dizziness
  • Dyspepsia