Clonazepam
Chemical
B2D
Use
- Tx epilepsy
- Anxiety
- Restless legs
Presentation
IV/PO tablets
Dose
0.5 – 5mg TDS (seizures)
Route
IV/PO
Onset
Peak levels 1 – 4hrs
MoA (mechanism)
- BZD receptor agonist
- Potentiates effects of GABA at GABA receptors
PD
CNS – antiepileptic, ↓neural transmission
PK
A
OBA 90%
D
85% PPB
?VD
M
Hepatic. CYP450; Reduction → then glucuronidation
E
Metabolites via kidneys
t ½ B 40hrs
Adverse Effects
- Fatigue
- Confusion
- ↓reflexes