Clonazepam

Chemical

B2D

Use

  1. Tx epilepsy
  2. Anxiety
  3. Restless legs

Presentation

IV/PO tablets

Dose

0.5 – 5mg TDS (seizures)

Route

IV/PO

Onset

Peak levels 1 – 4hrs

MoA (mechanism)

  • BZD receptor agonist
  • Potentiates effects of GABA at GABA receptors

PD

CNS – antiepileptic, ↓neural transmission

PK

A

OBA 90%

D

85% PPB

?VD

M

Hepatic. CYP450; Reduction → then glucuronidation

E

Metabolites via kidneys

t ½ B 40hrs

Adverse Effects

  • Fatigue
  • Confusion
  • ↓reflexes