Sodium Valproate
Chemical
Sodium salt of valproic acid
Use
- Tx epilepsy
- Chronic pain
- Mood stabiliser
Presentation
PO tablets
Vial of 400mg freeze dried powder for reconstitution
Dose
1 – 2g/day (starting with 600mg/day)
Route
PO/IV
Onset
2hrs (PO)
MoA (mechanism)
- Stabilises inactive Na+ channels
- Stimulates central GABA inhibitory pathways
PD
CNS – anticonvulsant
PK
A
Rapid & complete
100% OBA
D
90% PPB
VD 0.4L/kg
M
Liver
Oxidation & glucuronidase
Some active metabolites
E
t ½ B 8 – 20hrs
Metabolites excreted in urine
Clearance 11mL/kg/hr
Adverse Effects
- Hepatic dysfunction
- Acute pancreatitis
- Hair loss
- Oedema
- Weight gain