Digoxin Antibodies
Chemical
Antibody fragment
Use
Cardiac glycoside toxicity
Presentation
38mg vial
Dose
Dose varies based on amount of drug to be neutrolised
Average dose is 6 vials (228mg)
Route
IV
Onset
30 mins
DoA
15-20hrs
MoA
Specific antigen-binding fragments bing to free digoxin to prevent and reverse the pharmacological and toxic effects of Digoxin → removed from plasma
Then tissue bound digoxin is released into plasma → repeat
Cardiac toxicity begins to subside within 30mins after infusion is complete
PK
D
ECF
M
Unknown
E
Urinary excretion as the bound complex (digoxin immune Fab plus digoxin)
Adverse Effects
Hypokalaemia
Heart failure (reversal of digoxin effects)
Anaphylaxis
C/I
Allergy to sheep proteins
Still patented and expensive ($797 per 38mg vial)