Mannitol
Chemical
Osmotic diuretic
Use
↓ICP
Presentation
100g in 1000mL or 500mL (10%, 20%)
Sterile solutions
Dose
1g/kg over 15mins
MoA
- Small molecular weight substance
- Freely filtered by glomerulus
- Minimally reabsorbed
- Exerts osmotic force
- ↑urinary volume
*** Natriuresis only 10% filtered load because acts so early
PK
A
IV injection
D
VD 34L → confined to extracellular space
E
Minimally to glycogen
K
Unchanged in urine
t ½ B = 5hrs
Adverse Effects
Allergic response