Hydrocortisone

Chemical

Synthetic glucocorticoid

Use

Asthma, anaphylaxis

Presentation

Powder for injection

Oral tablet

Route/Dose

100 – 500mg QID IV

10 – 20mg daily PO

MoA

As for pred

PD

As for pred

PK

A

OBA 50%

Rectal 90%

D

90% PPB

V_D 0.3 – 0.5L/kg

M

Liver → tetra-hydrocortisone

E

Renal excretion

t ½ 6hrs

Adverse Effects

As for pred