F10vi: Outline the non-ventilatory functions of the lungs

A Firm Tits

Acid/Base

  • Part of the open ended system
  • Exhalation of CO2

Thermoregulation

  • Conducting airways warm & humidify inspired gas to body temp
  • Considerable insensible H2O loss for neonates

Filtration

  • Receives entire CO
  • Small thrombi/air filtered

Inhaled route

  • Access for delivery of drugs

Immunological

  • Mucociliary escalator
  • Pulmonary MFs
  • IgA secreted into mucous

Talking (phonation)

  • Adjustment of vocal cords during exhalation allows speech

Resevoir

  • Blood -> 400-500ml
  • Oxygen -> FRC
  • Drugs -> Fentanyl

Surfactant

  • T2 alveolar cells
  • ↓ST lungs

Metabolism

Synthetic

  • Protein -> collagen/elastin of lungs
  • CHO -> bronchial mucous polyssachs
  • PGIs -> VC, VD, plat aggr
  • Leukotrienes -> inflame & airway constriction

 Activation

  • AI → AII

 Inactivation

  • BK
  • 5HT
  • NA

Note

Taking up drugs allows SS concentration

Take up Basic Amines pKa >8

Lignocaine 50%

Fentanyl 75%

PPF 28%