K2i: The Ideal Sedative

Physical

• Stable in H₂O (pKa not at extreme ends)
• Stable in solution
• No reconstitution before use
• Stable in air & light
• Long shelf life
• Stored room temp
• Doesn’t support bacterial growth
• Compatible with other drugs & fluids in lines
• No additives
• Inexpensive

PK

• Rapid onset
• High oil/H₂O solubility
• Non-cumulative with infusion (low CSHT)
• Rapid & predictable recovery
• Completely metabolised to inactive + non-toxic metabolites
• Clearance not affected by organ dysfunction

PD

• Known MoA
• Known antagonist
• No pain on injection
• Safe if extravasates/intra-arterial injection
• No adverse drug reactions
• Smooth induction
• 1 arm-brain circulation time
• Anxiolytic, amnesic, analgesic, anti-emetic, anti-epileptic
• Muscle relaxation
• Ability to progress to GA
• No ↑CBF, ICP, IOP
• ↓CMRO₂
• Minimal CVS/Resp depression
• Nil histamine release
• No emergence phenomena
• Safe in pregnancy & paediatrics
• No teratogenicity